INS Antibody

• Gene Name:

  Insulin

• Gene Aliases:

  IDDM, ILPR, IRDN, IDDM1, IDDM2, PNDM4, MODY10

• Gene ID:

  3630

• Accession Number:

  NP_000198.1

• Reactivity:

  Chimpanzee

• Immunogen:

  Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Insulin. The exact sequence is proprietary.

• Target:

  After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

• Clonality:

  Monoclonal

• Clone:

  GT1455

• Type:

  Monoclonal Antibody

• Purification:

  Affinity purified by Protein A.

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1.82 mg/ml

• Format:

  Liquid// PBS

• Reconstitution:

  Keep as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

• Molecular Weight:

  12 kDa

• Fragment:

  IgG2b

• NCBI Gene Symbol:

  INS

• Host or Source:

  Mouse

• Protein Name:

  Insulin

• Gene Name URL:

  INS

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_000207.2