ERBB4 Antibody

• CAS Number :

  9007-83-4

• Gene Name :

  Erb-b2 receptor tyrosine kinase 4

• Gene Aliases :

  HER4, ALS19, p180erbB4

• Gene ID :

  2066

• Accession Number :

  NP_001036064.1

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant protein encompassing a sequence within the C-terminus region of human ERBB4. The exact sequence is proprietary.

• Target :

  This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

• Clonality :

  Polyclonal

• Type :

  Polyclonal Antibody

• Applications :

  ICC, IF, IHC-P, IP, WB

• Purification :

  Purified by antigen-affinity chromatography.

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  0.95 mg/ml

• Format :

  Liquid

• Buffer :

  0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7) . 0.01% Thimerosal was added as a preservative.

• Reconstitution :

  Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

• Fragment :

  IgG

• NCBI Gene Symbol :

  ERBB4

• Host or Source :

  Rabbit

• Protein Name :

  Receptor tyrosine-protein kinase erbB-4

• Gene Name URL :

  ERBB4

• Nucleotide Accession Number :

  NM_001042599.1