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TFRC Antibody

CAT: 0247-OAEE00963-100TSize: 100 TestsDry Ice: NoHazardous: No
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CAT#:0247-OAEE00963-100TSize:100 Tests
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CAS Number
9007-83-4
Gene Name
Transferrin receptor
Gene Aliases
CD71; IMD46; p90; T9; TFR; TFR1; TR; transferrin receptor protein 1; TRFR.
Gene ID
7037
Accession Number
NP_001121620.1NP_003225.2
Reactivity
Human
Immunogen
NALM-6 human pre-B cell line
Target
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240) .
Clonality
Monoclonal
Clone
MEM-75
Conjugation
FITC
Type
Monoclonal Antibody
Applications
Flow cytometry
Purification
Purified by size-exclusion chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
20 ul / test
Format
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Buffer
The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
HLDA IV; WS Code A 45 HLDA V; WS Code T T-165//
NCBI Gene Symbol
TFRC
Host or Source
Mouse
Protein Name
Transferrin receptor protein 1
Gene Name URL
TFRC
Nucleotide Accession Number
NM_001128148.1NM_003234.2

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