CD74 Antibody

• Gene Name :

  HLA class II histocompatibility antigen gamma chain

• Gene Aliases :

  II, p33, DHLAG, HLADG, Ia-GAMMA

• Gene ID :

  972

• Accession Number :

  NP_001020329.1NP_001020330.1NP_004346.1

• Reactivity :

  Mouse

• Immunogen :

  Activated C57BL/6 mouse spleen cells

• Target :

  MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.

• Clonality :

  Monoclonal

• Clone :

  M5/114

• Type :

  Monoclonal Antibody

• Applications :

  Flow cytometry|Functional assay|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot

• Purification :

  Purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1 mg/ml

• Format :

  Phosphate buffered saline (PBS), pH 7.4

• Reconstitution :

  2°C to 8°C

• Fragment :

  IgG2b

• Specificity :

  The rat monoclonal antibody M5/114 reacts with murine MHC class II glycoproteins. It recognizes a shared determinant on I-Ab, I-Ad, I-Aq, and I-Ed, I-Ek alloantigens, but it does not react with I-Af, I-Ak, I-As. This antibody can inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not H-2f, H-2k, H-2s haplotypes.

• NCBI Gene Symbol :

  CD74

• Host or Source :

  Rat

• Protein Name :

  HLA class II histocompatibility antigen gamma chain

• Gene Name URL :

  CD74

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_001025158.2NM_001025159.2NM_004355.3