CD74 Antibody

CAT: 0247-OAEE00498-100UGSize: 0.1 mg (C100)Dry Ice: NoHazardous: No
CAT#:0247-OAEE00498-100UGSize:0.1 mg (C100)
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CAS Number
9007-83-4
Gene Name
HLA class II histocompatibility antigen gamma chain
Gene Aliases
II, p33, DHLAG, HLADG, Ia-GAMMA
Gene ID
972
Accession Number
NP_001020329.1NP_001020330.1NP_004346.1
Reactivity
Mouse
Immunogen
Activated C57BL/6 mouse spleen cells
Target
MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.
Clonality
Monoclonal
Clone
M5/114
Type
Monoclonal Antibody
Applications
Flow cytometry|Functional assay|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Phosphate buffered saline (PBS), pH 7.4
Reconstitution
2°C to 8°C
Fragment
IgG2b
Specificity
The rat monoclonal antibody M5/114 reacts with murine MHC class II glycoproteins. It recognizes a shared determinant on I-Ab, I-Ad, I-Aq, and I-Ed, I-Ek alloantigens, but it does not react with I-Af, I-Ak, I-As. This antibody can inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not H-2f, H-2k, H-2s haplotypes.
NCBI Gene Symbol
CD74
Host or Source
Rat
Protein Name
HLA class II histocompatibility antigen gamma chain
Gene Name URL
CD74
Nucleotide Accession Number
NM_001025158.2NM_001025159.2NM_004355.3

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