CD40 Antibody

• Gene Name:

  Cd4 molecule|CD40 molecule

• Gene Aliases:

  B cell surface antigen CD40; B cell-associated molecule; Bp50; CD4 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDW40; p50; p55; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; TNFRSF5; tumor necrosis factor receptor superfamily member 5; W3/25; W3/25 antigen.

• Gene ID:

  24932|958

• Accession Number:

  NP_001241.1NP_001289682.1NP_690593.1

• Reactivity:

  Human

• Immunogen:

  Human CD40a

• Target:

  Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs) . In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.

• Clonality:

  Monoclonal

• Clone:

  HI40a

• Type:

  Monoclonal Antibody

• Applications:

  Flow cytometry

• Purification:

  Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Format:

  Phosphate buffered saline (PBS), pH 7.4

• Buffer:

  Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized.

• Reconstitution:

  2°C to 8°C

• Fragment:

  IgG1

• Specificity:

  The antibody HI40a recognizes CD40 (BP50), a 48 kDa type I single chain transmembrane glycoprotein expressed on normal and neoplastic B cells, but not on terminally differentiated plasma cells. CD40 antigen is also present on Hodgkin's and Reed-Sternberg cells, follicular dendritic cells, some macrophages, basal epithelial cells and endothelial cells.

• NCBI Gene Symbol:

  Cd4|CD40

• Host or Source:

  Mouse

• Protein Name:

  T-cell surface glycoprotein CD4

• Gene Name URL:

  Cd4|CD40

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001250.5NM_001302753.1NM_152854.3