CD14 Antibody

• Gene Name :

  CD14 molecule

• Gene Aliases :

  Monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein.

• Gene ID :

  929

• Accession Number :

  NP_000582.1NP_001035110.1NP_001167575.1NP_001167576.1

• Reactivity :

  Human

• Immunogen :

  Human monocytes

• Target :

  Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655) . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135) . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211) . Binds electronegative LDL (LDL (-) ) and mediates the cytokine release induced by LDL (-) (PubMed:23880187) .

• Clonality :

  Monoclonal

• Clone :

  B-A8

• Type :

  Monoclonal Antibody

• Applications :

  Enzyme-linked immunosorbent assay|Flow cytometry|Immunohistochemistry-Paraffin

• Purification :

  Purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1 mg/ml

• Format :

  Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• Buffer :

  Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

• Reconstitution :

  2°C to 8°C

• Fragment :

  IgG1

• Specificity :

  The antibody B-A8 reacts with CD14, a 53-55 kDa GPI (glycosylphosphatidylinositol) -linked membrane glycoprotein expressed on monocytes, macrophages and weakly on granulocytes; also expressed by most tissue macrophages.

• NCBI Gene Symbol :

  CD14

• Host or Source :

  Mouse

• Protein Name :

  Monocyte differentiation antigen CD14

• Gene Name URL :

  CD14

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_000591.3NM_001040021.2NM_001174104.1NM_001174105.1