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HSPA8 Antibody

CAT: 0247-OAED00156-50UGSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0247-OAED00156-50UGSize:50 µg
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CAS Number
9007-83-4
Gene Name
Heat shock protein family A (Hsp70) member 6
Gene Aliases
Epididymis secretory sperm binding protein; heat shock 70 kDa protein 6; heat shock 70 kDa protein B'; heat shock 70kD protein 6 (HSP70B') ; heat shock 70kDa protein 6 (HSP70B') ; HSP70B'.
Gene ID
3310
Accession Number
NP_006588.1NP_694881.1
Reactivity
Human
Immunogen
Synthetic peptide corresponding to the sequence near the C-terminus of human HSP70B.
Target
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365) .
Clonality
Monoclonal
Clone
165f
Type
Monoclonal Antibody
Applications
Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Reconstitution
Long Term Storage : //-20C
Fragment
IgG1
Specificity
Recognizes human HSP70B. Detects a band of ~70kDa by Western blot.
NCBI Gene Symbol
HSPA6
Host or Source
Mouse
Protein Name
Heat shock 70 kDa protein 6
Gene Name URL
HSPA6
Nucleotide Accession Number
NM_006597.5NM_153201.3

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