CD45 Antibody

• Gene Name:

  Protein tyrosine phosphatase, receptor type C

• Gene Aliases:

  LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180

• Gene ID:

  5788

• Accession Number:

  NP_002829.3

• Reactivity:

  Human

• Target:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

• Clonality:

  Monoclonal

• Clone:

  B-A11

• Type:

  Monoclonal Antibody

• Applications:

  FC

• Purification:

  Affinity chromatography

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 ug/uL

• Format:

  Liquid

• Buffer:

  Phosphate-buffered saline. Sterile-filtered through 0.22 um. Carrier and preservative free

• Reconstitution:

  Stable at +2-8C for 12 months. For longer storage, freeze aliquots

• Molecular Weight:

  147 kDa

• Fragment:

  Mouse IgG1

• Specificity:

  Recognises the Leucocyte Common Antigen (LCA) with different isoforms of 180-190-205-220 kDa

• NCBI Gene Symbol:

  CD45

• Host or Source:

  Human

• Protein Name:

  Receptor-type tyrosine-protein phosphatase C

• Gene Name URL:

  CD45

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_002838.4