CD253 Antibody

• Gene Name:

  Tumor necrosis factor superfamily member 10

• Gene Aliases:

  TL2, APO2L, CD253, TRAIL, Apo-2L, TNLG6A

• Gene ID:

  8743

• Accession Number:

  NP_001177871.1

• Reactivity:

  Human

• Target:

  The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Clonality:

  Monoclonal

• Clone:

  B-S23

• Type:

  Monoclonal Antibody

• Purification:

  Ion exchange chromatography

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/mL

• Format:

  Lyophilized

• Reconstitution:

  Store at +2-8C for 12 months. For longer storage, freeze aliquots at -20C

• Molecular Weight:

  33 kDa

• Fragment:

  IgG1

• Specificity:

  Recognises TRAIL, APO2L antigen, a 32kDa protein

• NCBI Gene Symbol:

  CD253

• Host or Source:

  Mouse

• Protein Name:

  Tumor necrosis factor ligand superfamily member 10

• Gene Name URL:

  CD253

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001190942.1