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TICAM2 Antibody

CAT: 0247-OACD07750-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0247-OACD07750-100ULSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
TMED7-TICAM2 readthrough|toll like receptor adaptor molecule 2
Gene Aliases
Cytoplasmic adaptor; MyD88-4; NF-kappa-B-activating protein 502; putative NF-kappa-B-activating protein 502; TICAM2; TICAM-2; TIR domain-containing adapter molecule 2; TIRAP3; TIRP; TMED7-TICAM2 read-through transcript; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; toll-like receptor adaptor protein 3; TRAM; TRAM adaptor with GOLD domain; TRIF-related adapter molecule; TRIF-related adaptor molecule.
Gene ID
100302736|353376
Accession Number
NP_001157940.1
Reactivity
Human
Immunogen
Range: Ser22 - Gln205
Target
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
27 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against TICAM2. It has been selected for its ability to recognize TICAM2 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
TICAM2|TMED7-TICAM2
Host or Source
Rabbit
Protein Name
TIR domain-containing adapter molecule 2
Gene Name URL
TICAM2|TMED7-TICAM2
Nucleotide Accession Number
NM_001164468

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