MAP2K7 Antibody

CAT: 0247-OACD05422-1MLSize: 1 mLDry Ice: NoHazardous: No
CAT#:0247-OACD05422-1MLSize:1 mL
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CAS Number
9007-83-4
Gene Name
Mitogen-activated protein kinase kinase 7
Gene Aliases
C-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7; JNK-activating kinase 2; JNKK2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK7; MEK; MEK 7; MKK7; PRKMK7; SAPK kinase 4; SAPKK4; SAPKK-4; stress-activated protein kinase kinase 4.
Gene ID
5609
Accession Number
NP_001284484.1
Reactivity
Human|Mouse|Porcine|Rat
Immunogen
Range: Tyr113 - Val388
Target
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
47 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against MAP2K7. It has been selected for its ability to recognize MAP2K7 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
MAP2K7
Host or Source
Rabbit
Protein Name
Dual specificity mitogen-activated protein kinase kinase 7
Gene Name URL
MAP2K7
Nucleotide Accession Number
NM_001297555

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