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KLRB1 Antibody

CAT: 0247-OACD05024-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0247-OACD05024-100ULSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Killer cell lectin like receptor B1
Gene Aliases
CD161; CLEC5B; C-type lectin domain family 5 member B; hNKR-P1A; killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B, member 1; natural killer cell surface protein P1A; NKR; NKR-P1; NKRP1A; NKR-P1A.
Gene ID
3820
Accession Number
NP_002249.1
Reactivity
Human|Porcine|Rat
Immunogen
Range: Lys73 - Ser188
Target
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha (1,3) Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
25 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against KLRB1. It has been selected for its ability to recognize KLRB1 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
KLRB1
Host or Source
Rabbit
Protein Name
Killer cell lectin-like receptor subfamily B member 1
Gene Name URL
KLRB1
Nucleotide Accession Number
NM_002258

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