Products for Research Use Only
RegisterLogin

KLRK1 Antibody

CAT: 0247-OAEE00808-100TSize: 100 TestsDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OAEE00808-100TSize:100 Tests
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
9007-83-4
Gene Name
Killer cell lectin like receptor K1|KLRC4-KLRK1 readthrough
Gene Aliases
CD314; D12S2489E; killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; NK cell receptor D; NKG2D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor.
Gene ID
100528032|22914
Accession Number
NP_001186734.1NP_031386.2
Reactivity
Human
Immunogen
NKL cell line
Target
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8 (+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Clonality
Monoclonal
Clone
1D11
Conjugation
R-PE
Type
Monoclonal Antibody
Applications
Flow cytometry
Purification
Purified by size-exclusion chromatography
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
10 ul / test
Format
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Buffer
The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
The mouse monoclonal antibody 1D11 recognizes CD314 / NKG2D, a 42 kDa C-type lectin-like activating receptor expressed by NK cells, gamma/delta T cells, and CD8+ T cells.
NCBI Gene Symbol
KLRC4-KLRK1|KLRK1
Host or Source
Mouse
Protein Name
NKG2-D type II integral membrane protein
Gene Name URL
KLRC4-KLRK1|KLRK1
Nucleotide Accession Number
NM_001199805.1NM_007360.3

Related Products

CatalogName
OPCD00718-200UGKLRK1 Recombinant Protein
OPCD00735-10UGKLRK1 Recombinant Protein
OPCD00735-50UGKLRK1 Recombinant Protein
OPCD00718-10UGKLRK1 Recombinant Protein
OPCD00716-50UGKLRK1 Recombinant Protein
OPCD00716-200UGKLRK1 Recombinant Protein
OPCD00735-200UGKLRK1 Recombinant Protein
OPCD00718-50UGKLRK1 Recombinant Protein
OPCD00716-10UGKLRK1 Recombinant Protein
OKCA01392KLRK1 ELISA Kit (Human) (OKCA01392)

Alternative Products

CatalogName
GWB-MW826GKLRK1 Antibody

Popular Products