GREM1 Antibody

• Gene Name:

  Gremlin 1, DAN family BMP antagonist

• Gene Aliases:

  Cktsf1b1; cysteine knot superfamily 1, BMP antagonist 1; down-regulated in Mos-transformed cells protein; drm; gremlin 1 homolog, cysteine knot superfamily; gremlin-1.

• Gene ID:

  50566

• Accession Number:

  NP_062155.1

• Reactivity:

  Human|Mouse|Rat

• Immunogen:

  Recombinant GREM1 (Lys25~Asp184) expressed in E.coli.

• Target:

  Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity) . Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity) . Acts as inhibitor of monocyte chemotaxis (PubMed:15528323) . Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

• Purification:

  Affinity Purified; Protein A Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Format:

  Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

• Reconstitution:

  2°C to 8°C|-20°C

• Molecular Weight:

  21 kDa

• Fragment:

  IgG

• Specificity:

  The antibody is a rabbit polyclonal antibody raised against GREM1. It has been selected for its ability to recognize GREM1 in immunohistochemical staining and western blotting.

• NCBI Gene Symbol:

  Grem1

• Host or Source:

  Rabbit

• Protein Name:

  Gremlin-1

• Gene Name URL:

  Grem1

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_019282