EIF2AK3 Antibody

• Gene Name :

  Eukaryotic translation initiation factor 2 alpha kinase 3

• Gene Aliases :

  Eukaryotic translation initiation factor 2-alpha kinase 3; pancreatic eIF2-alpha kinase; PE; Pek; Perk; PRKR-like endoplasmic reticulum kinase.

• Gene ID :

  13666

• Accession Number :

  NP_001300847.1

• Reactivity :

  Mouse|Porcine

• Immunogen :

  Range: Met973 - Asn1114

• Target :

  Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability (PubMed:11106749) . Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:23921556) . Serves as a critical effector of unfolded protein response (UPR) -induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (PubMed:11035797) . Involved in control of mitochondrial morphology and function (PubMed:23921556) .

• Clonality :

  Polyclonal

• Type :

  Polyclonal Antibody

• Applications :

  Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

• Purification :

  Affinity Purified; Protein A Purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  0.5 mg/ml

• Format :

  Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

• Reconstitution :

  2°C to 8°C|-20°C

• Molecular Weight :

  125 kDa

• Fragment :

  IgG

• Specificity :

  The antibody is a rabbit polyclonal antibody raised against EIF2aK3. It has been selected for its ability to recognize EIF2aK3 in immunohistochemical staining and western blotting.

• NCBI Gene Symbol :

  Eif2ak3

• Host or Source :

  Rabbit

• Protein Name :

  Eukaryotic translation initiation factor 2-alpha kinase 3

• Gene Name URL :

  Eif2ak3

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_001313918