A2ML1 Antibody

• Gene Name :

  Alpha-2-macroglobulin like 1

• Gene Aliases :

  Alpha-2-macroglobulin-like protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; CPAMD9; OMS; p170.

• Gene ID :

  144568

• Accession Number :

  NP_001269353.1

• Reactivity :

  Horse|Human

• Immunogen :

  Range: Gln1119 - Thr1348

• Target :

  Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced) . Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity) . Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.

• Clonality :

  Polyclonal

• Type :

  Polyclonal Antibody

• Applications :

  Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot

• Purification :

  Affinity Purified; Protein A Purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  0.5 mg/ml

• Format :

  Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

• Reconstitution :

  2°C to 8°C|-20°C

• Molecular Weight :

  106 kDa

• Fragment :

  IgG

• Specificity :

  The antibody is a rabbit polyclonal antibody raised against a2ML1. It has been selected for its ability to recognize a2ML1 in immunohistochemical staining and western blotting.

• NCBI Gene Symbol :

  A2ML1

• Host or Source :

  Rabbit

• Protein Name :

  Alpha-2-macroglobulin-like protein 1

• Gene Name URL :

  A2ML1

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_001282424