Products for Research Use Only
RegisterLogin

PHF8 Antibody

CAT: 0247-OACD00962-100ULSize: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OACD00962-100ULSize:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
9007-83-4
Gene Name
PHD finger protein 8|PHD finger protein 8, pseudogene
Gene Aliases
[histone H3]-dimethyl-L-lysine (36) demethylase PHF8; [histone H3]-dimethyl-L-lysine (9) demethylase PHF8;4921501E09Rik;9830141C09Rik; histone lysine demethylase PHF8; KIAA1111-like protein; mKIAA1111; PHD finger protein 8; PHF8.
Gene ID
320595|74042
Accession Number
NP_001009544.1
Reactivity
Human|Mouse|Rat
Immunogen
Range: Phe195 - Lys351
Target
Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1) . Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
53 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against PHF8. It has been selected for its ability to recognize PHF8 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Phf8|Phf8-ps
Host or Source
Rabbit
Protein Name
Histone lysine demethylase PHF8
Gene Name URL
Phf8|Phf8-ps
Nucleotide Accession Number
NM_001009544

Related Products

CatalogName
OPCD00650-10UGPHF8 Recombinant Protein
OPCD00650-50UGPHF8 Recombinant Protein
OCOA21249-20UGPHF8 Protein Lysate
OPCD00650-200UGPHF8 Recombinant Protein
OKCD01031-96WPHF8 ELISA Kit (Mouse)
OKCD01031PHF8 ELISA Kit (Mouse) (OKCD01031)
OAAL00237-100UGPHF1 Antibody
OAAN02254-200ULPHF6 Antibody
OAAF04002-100UGPHF3 Antibody
OAAH00027-100ULPHF6 Antibody

Alternative Products

CatalogName
MBS850315-01PHF8 Antibody
STJ98531Anti-PHF8 antibody
MBS388551-01PHF8 antibody (pAb)
BS91068PHF8 polyclonal antibody
C48558PHF8 Conjugated Antibody
GTR18219012-01Rabbit PHF8 Antibody
bsm-60652R-01PHF8 Recombinant Antibody
RC-16677-01Recombinant PHF8 Antibody
HY-P82579-01PHF8 Antibody (YA2324, Rabbit)
NB100-93313Rabbit Polyclonal PHF8 Antibody

Popular Products