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TOPBP1 Antibody

CAT: 0247-OACD00492-1MLSize: 1 mLDry Ice: NoHazardous: No
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CAT#:0247-OACD00492-1MLSize:1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Topoisomerase (DNA) II binding protein 1
Gene Aliases
1110031N14Rik;2810429C13Rik; AI256758; D430026L04Rik; DNA topoisomerase 2-binding protein 1; DNA topoisomerase II-beta-binding protein 1; DNA topoisomerase II-binding protein 1; mKIAA0259; topoisomerase (DNA) II beta binding protein.
Gene ID
235559
Accession Number
NP_795953.2
Reactivity
Human|Mouse|Rat
Immunogen
Range: Met1 - Pro246
Target
Required for DNA replication (By similarity) . Plays a role in the rescue of stalled replication forks and checkpoint control (PubMed:14718568) . Binds double-stranded DNA breaks and nicks as well as single-stranded DNA (By similarity) . Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity) . Induces a large increase in the kinase activity of ATR (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
169 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against TOPBP1. It has been selected for its ability to recognize TOPBP1 in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Topbp1
Host or Source
Rabbit
Protein Name
DNA topoisomerase 2-binding protein 1
Gene Name URL
Topbp1
Nucleotide Accession Number
NM_176979

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