FGF1 Antibody

CAT: 0247-OACD00107-1MLSize: 1 mLDry Ice: NoHazardous: No
CAT#:0247-OACD00107-1MLSize:1 mL
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CAS Number
9007-83-4
Gene Name
Fibroblast growth factor 1
Gene Aliases
Acidic fibroblast growth factor; aFGF; FGF-1; Fgf2b; fibroblast growth factor 1; fibroblast growth factor 1 (acidic) ; Fibroblast growth factor 1 (heparin binding) ; fibroblast growth factor 2b; HBGF1; HBGF-1; heparin-binding growth factor 1.
Gene ID
25317
Accession Number
NP_036978.1
Reactivity
Rat
Immunogen
Fgf1 Recombinant Protein (OPCD03184)
Target
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.
Clonality
Monoclonal
Clone
C3
Type
Monoclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Protein A/G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid. PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Fragment
IgG2b Kappa
NCBI Gene Symbol
Fgf1
Host or Source
Mouse
Protein Name
Fibroblast growth factor 1
Gene Name URL
Fgf1
Nucleotide Accession Number
NM_012846.1

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