PAN2 Antibody

• Gene Name :

  Poly (A) specific ribonuclease subunit PAN2

• Gene Aliases :

  Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly (A) -nuclease; PAB1P-dependent poly (A) -specific ribonuclease; PAB-dependent poly (A) -specific ribonuclease subunit 2; PAB-dependent poly (A) -specific ribonuclease subunit PAN2; PABP-dependent poly (A) nuclease 2; PAN deadenylation complex catalytic subunit 2; PAN deadenylation complex subunit 2; PAN2 poly (A) specific ribonuclease subunit homolog; PAN2-PAN3 deadenylation complex catalytic subunit PAN2; poly (A) -nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52; USP52.

• Gene ID :

  9924

• Accession Number :

  NP_001120932

• Reactivity :

  Human

• Immunogen :

  Recombinant Human PAB-dependent poly (A) -specific ribonuclease subunit PAN2 protein (628-908AA)

• Target :

  Catalytic subunit of the poly (A) -nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly (A) tails of RNA and the activity is stimulated by poly (A) -binding protein (PABP) . PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly (A) tail length regulation.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry

• Purification :

  Protein G Purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format :

  Liquid

• Reconstitution :

  -20°C or -80°C

• Fragment :

  IgG

• NCBI Gene Symbol :

  PAN2

• Host or Source :

  Rabbit

• Protein Name :

  PAN2-PAN3 deadenylation complex catalytic subunit PAN2

• Gene Name URL :

  PAN2

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_001127460