PAN2 Antibody

• Gene Name:

  Poly (A) specific ribonuclease subunit PAN2

• Gene Aliases:

  Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly (A) -nuclease; PAB1P-dependent poly (A) -specific ribonuclease; PAB-dependent poly (A) -specific ribonuclease subunit 2; PAB-dependent poly (A) -specific ribonuclease subunit PAN2; PABP-dependent poly (A) nuclease 2; PAN deadenylation complex catalytic subunit 2; PAN deadenylation complex subunit 2; PAN2 poly (A) specific ribonuclease subunit homolog; PAN2-PAN3 deadenylation complex catalytic subunit PAN2; poly (A) -nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52; USP52.

• Gene ID:

  9924

• Accession Number:

  NP_001120932

• Reactivity:

  Human

• Immunogen:

  Recombinant Human PAB-dependent poly (A) -specific ribonuclease subunit PAN2 protein (628-908AA)

• Target:

  Catalytic subunit of the poly (A) -nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly (A) tails of RNA and the activity is stimulated by poly (A) -binding protein (PABP) . PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly (A) tail length regulation.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry

• Purification:

  Protein G Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format:

  Liquid

• Reconstitution:

  -20°C or -80°C

• Fragment:

  IgG

• NCBI Gene Symbol:

  PAN2

• Host or Source:

  Rabbit

• Protein Name:

  PAN2-PAN3 deadenylation complex catalytic subunit PAN2

• Gene Name URL:

  PAN2

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001127460