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PANK2 Antibody

CAT: 0247-OAAL00824-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAL00824-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Pantothenate kinase 2
Gene Aliases
C20orf48; Hallervorden-Spatz syndrome; HARP; HSS; NBIA1; pantothenate kinase 2, mitochondrial; pantothenate kinase-associated neurodegeneration; pantothenic acid kinase 2; PKAN.
Gene ID
80025
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_705902
Reactivity
Human, Mouse
Immunogen
PANK2 (NP_705902, 205 a.a. ~ 259 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Target
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq
Clonality
Monoclonal
Clone
2B12
Type
Monoclonal Antibody
Sequence
IGDLQLCKLDELDCLIKGILYIDSVGFNGRSQCYYFENPADSEKCQKLPFDLKNP
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry-Paraffin|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
Store at -20C or lower. Aliquot to avoid repeated freezing and thawing.
Fragment
IgG2a Kappa
NCBI Gene Symbol
PANK2
Host or Source
Mouse
Protein Name
Homo sapiens pantothenate kinase 2 (PANK2), transcript variant 1, mRNA|pantothenate kinase 2, mitochondrial isoform 1 precursor [Homo sapiens]
Gene Name URL
PANK2
Nucleotide Accession Number
https://www.ncbi.nlm.nih.gov/nuccore/NM_153638

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