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NMNAT1 Antibody

CAT: 0247-OACA08085-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAS Number
9007-83-4
Gene Name
Nicotinamide nucleotide adenylyltransferase 1
Gene Aliases
LCA9; NaMN adenylyltransferase 1; nicotinamide mononucleotide adenylyltransferase 1; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Nicotinamide-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; NMNAT; PNAT1; pyridine nucleotide adenylyltransferase 1; SHILCA.
Gene ID
64802
Accession Number
NP_001284707
Reactivity
Human
Immunogen
Recombinant Human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 protein (1-279AA)
Target
Catalyzes the formation of NAD (+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747) . Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747) . Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747) . Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD (+) (PubMed:17402747) . For the pyrophosphorolytic activity, prefers NAD (+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747) . Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257) . Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257) . Fails to cleave phosphorylated dinucleotides NADP (+), NADPH and NaADP (+) (PubMed:17402747) . Protects against axonal degeneration following mechanical or toxic insults (By similarity) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
NMNAT1
Host or Source
Rabbit
Protein Name
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
Gene Name URL
NMNAT1
Nucleotide Accession Number
NM_001297778

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