DCP2 Antibody

• Gene Name :

  Decapping mRNA 2

• Gene Aliases :

  DCP2 decapping enzyme homolog; hDpc; m7GpppN-mRNA hydrolase; mRNA-decapping enzyme 2; Nucleoside diphosphate-linked moiety X motif 20; nudix (nucleoside diphosphate linked moiety X) -type motif 20; NUDT20.

• Gene ID :

  167227

• Accession Number :

  NP_001229306

• Reactivity :

  Human

• Immunogen :

  Recombinant Human m7GpppN-mRNA hydrolase protein (1-240AA)

• Target :

  Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968) . Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968) . Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413) . Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165) . Has higher activity towards mRNAs that lack a poly (A) tail (PubMed:21070968) . Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968) . Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot

• Purification :

  Affinity Purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format :

  Liquid

• Reconstitution :

  -20°C or -80°C

• Fragment :

  IgG

• NCBI Gene Symbol :

  DCP2

• Host or Source :

  Rabbit

• Protein Name :

  M7GpppN-mRNA hydrolase

• Gene Name URL :

  DCP2

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_001242377