PAK4 Antibody

CAT: 0247-OACA04096-50UGSize: 50 µgDry Ice: NoHazardous: No
CAT#:0247-OACA04096-50UGSize:50 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
9007-83-4
Gene Name
P21 (RAC1) activated kinase 4
Gene Aliases
P21 protein (Cdc42/Rac) -activated kinase 4; p21 (CDKN1A) -activated kinase 4; p21-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; serine/threonine-protein kinase PAK 4.
Gene ID
10298
Accession Number
NP_001014831
Reactivity
Human|Rat
Immunogen
Recombinant Human Serine/threonine-protein kinase PAK 4 protein (1-426AA)
Target
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Western blot
Purification
Protein G Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
-20°C or -80°C
Fragment
IgG
NCBI Gene Symbol
PAK4
Host or Source
Rabbit
Protein Name
Serine/threonine-protein kinase PAK 4
Gene Name URL
PAK4
Nucleotide Accession Number
NM_001014831

Related Products

CatalogName
OPPA01711-5UGPAK4 Protein
OACA12192-100ULPhospho-PAK4/PAK5/PAK6 (S474/S560/S602) Recombinant Antibody [2D1] (OACA12192)
OCOA16455-20UGPAK4 Protein Lysate
OCOA16457-20UGPAK4 Protein Lysate
OPCD05969-50UGPAK4 Recombinant Protein
OPCD05969-10UGPAK4 Recombinant Protein
OCOA12384-20UGPAK4 Protein Lysate
OPCD05969-200UGPAK4 Recombinant Protein
OCOA16456-20UGPAK4 Protein Lysate
OPCA03915-100UGPAK4 Recombinant Protein (Human)

Alternative Products

CatalogName
A18922-50UGPAK4 Antibody

Popular Products