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RASA1 Antibody

CAT: 0247-OAAL00277-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAL00277-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
RAS p21 protein activator 1
Gene Aliases
CMAVM; CM-AVM; CMAVM1; GAP; p120; p120 RAS GTPase activating protein; p120GAP; p120RASGAP; PKWS; ras GTPase-activating protein 1; RAS p21 protein activator (GTPase activating protein) 1; RASA; RASGAP; triphosphatase-activating protein.
Gene ID
5921
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_002881
Reactivity
Human, Mouse
Immunogen
RASA1 (NP_002881, 948 a.a. ~ 1047 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Target
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq
Clonality
Monoclonal
Clone
1000000
Type
Monoclonal Antibody
Sequence
AKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid
Reconstitution
Store at -20C or lower. Aliquot to avoid repeated freezing and thawing.
Fragment
IgG1 Kappa
NCBI Gene Symbol
RASA1
Host or Source
Mouse
Protein Name
Homo sapiens RAS p21 protein activator 1 (RASA1), transcript variant 1, mRNA|ras GTPase-activating protein 1 isoform 1 [Homo sapiens]
Gene Name URL
RASA1
Nucleotide Accession Number
https://www.ncbi.nlm.nih.gov/nuccore/NM_002890

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