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MAP3K3 Antibody

CAT: 0247-OAAH00044-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0247-OAAH00044-100ULSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Mitogen-activated protein kinase kinase kinase 3
Gene Aliases
MEKK3, MAPKKK3
Gene ID
4215
Swiss Prot
Q99759
Accession Number
NP_002392.2NP_976226.1
Reactivity
Human, Monkey
Immunogen
This Aviva monoclonal antibody is produced by immunizing mice with a polypeptide (Aviva SEAL mAb technology) corresponding to surface multi-epitopes of human MEKK3.
Target
This gene product is a 657-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB) -dependent reporter gene, consistent with a role in the SAPK pathway.
Clonality
Monoclonal
Type
Monoclonal Antibody
Source
Mouse mAb
Applications
WB
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Molecular Weight
74 kDa
Fragment
Mouse IgG
Specificity
MEKK3 monoclonal antibody detects endogenous levels of MEKK3 protein.
Protein Length
657
NCBI Gene Symbol
MAP3K3
Host or Source
Mouse
Protein Name
Mitogen-activated protein kinase kinase kinase 3
Gene Name URL
MAP3K3
Nucleotide Accession Number
NM_002401.3NM_203351.1

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