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CLDN18 Antibody

CAT: 0247-OAAF08291-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0247-OAAF08291-100ULSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Claudin 18
Gene Aliases
SFTA5, SFTPJ
Gene ID
51208
Swiss Prot
P56856
Accession Number
NP_001002026.1
Immunogen
The antiserum was produced against synthesized peptide derived between 220-261 aa of human CLDN18. The exact sequence is proprietary.
Target
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
Clonality
Monoclonal
Clone
ABT-CLD18
Type
Monoclonal Antibody
Applications
IHC-P
Purification
Immunogen affinity purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid. Supplied in 1% BSA, 0.05M Tris-HCl, 0.15M NaCl, 0.2% Kathon CG/ICP, 0.1% Tween-20
Reconstitution
Shipped at 4C. Store at -20C. Stable for 12 months at -20C.
Molecular Weight
28Â kDa
Fragment
IgG
Specificity
Anti-Claudin 18 [ABT-CLD18] detects endogenous levels of total Claudin 18 protein.
NCBI Gene Symbol
CLDN18
Host or Source
Mouse
Protein Name
Claudin-18
Gene Name URL
CLDN18
Nucleotide Accession Number
NM_001002026.2

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