ENG Antibody

• Gene Name :

  Endoglin

• Gene Aliases :

  CD105 antigen; END; endoglin; HHT1; ORW1.

• Gene ID :

  2022

• Swiss Prot :

  P17813

• Accession Number :

  NP_000109.1

• Reactivity :

  Human

• Immunogen :

  Synthetic peptide.

• Target :

  Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529) . Required for normal structure and integrity of adult vasculature (PubMed:7894484) . Regulates the migration of vascular endothelial cells (PubMed:17540773) . Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity) . May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity) . May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830) . Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529) . Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529) .

• Clonality :

  Monoclonal

• Clone :

  ABT-CD105

• Type :

  Monoclonal Antibody

• Applications :

  Immunohistochemistry

• Purification :

  Immunogen affinity purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Format :

  PBS, pH7.2, 0.03% Proclin 300, 50% glycerol

• Reconstitution :

  -20°C

• Molecular Weight :

  70 kDa

• Fragment :

  IgG

• Specificity :

  Anti-CD105 (Endoglin) [ABT-CD105] detects endogenous levels of total CD105 (Endoglin) protein.

• NCBI Gene Symbol :

  ENG

• Host or Source :

  Mouse

• Protein Name :

  Endoglin

• Gene Name URL :

  ENG

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_000118.3