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TUT1 Antibody

CAT: 0247-OAAF04400-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF04400-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Terminal uridylyl transferase 1, U6 snRNA-specific
Gene Aliases
Nuclear speckle targeted phosphatidylinositol 4-phosphate 5-kinase type I-alpha regulated-poly (A) polymerase; nuclear speckle-targeted PIPK1A-regulated-poly (A) polymerase; PAP-associated domain-containing 2; PAPD2; poly (A) polymerase associated domain containing 2; RBM21; RNA uridylyltransferase; RNA-binding motif protein 21; RNA-binding protein 21; speckle targeted PIP5K1A-regulated poly (A) polymerase; star-PAP; STARPAP; TENT1; TUTase; TUTase 6; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase; up-regulated in lung cancer 6; URLC6.
Gene ID
64852
Swiss Prot
Q9H6E5
Accession Number
NP_073741.2
Reactivity
Human|Mouse|Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human TUT1.
Target
Poly (A) polymerase that creates the 3'-poly (A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly (A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
93 kDa
Specificity
TUT1 antibody detects endogenous levels of total TUT1 protein.
NCBI Gene Symbol
TUT1
Host or Source
Rabbit
Protein Name
Speckle targeted PIP5K1A-regulated poly (A) polymerase
Gene Name URL
TUT1

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