PPP1R16B Antibody

9007-83-4

Protein phosphatase 1 regulatory subunit 16B

ANKRD4; ankyrin repeat domain protein 4; ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; hTIMAP; protein phosphatase 1 regulatory inhibitor subunit 16B; protein phosphatase 1, regulatory (inhibitor) subunit 16B; TGF-beta-inhibited membrane-associated protein; TIMAP.

26051

Q96T49

NP_001166206.1

Human|Mouse

The antiserum was produced against synthesized peptide derived from human PPP1R16B.

Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956) . Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873) . Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity) . Protects the endothelial barrier from lipopolysaccharide (LPS) -induced vascular leakage (By similarity) . Involved in the regulation of endothelial cell filopodia extension (By similarity) . May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956) . Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956) . Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087) . Involved in the dephosphorylation of EEF1A1 (PubMed:26497934) .

Polyclonal Antibody

Enzyme-linked immunosorbent assay|Western blot

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

The optimal working dilution should be determined by the end user.

Liquid

-20°C

63 kDa

Formerly GWB-ASE877

PPP1R16B antibody detects endogenous levels of total PPP1R16B protein.

PPP1R16B

Rabbit

Protein phosphatase 1 regulatory inhibitor subunit 16B