CCRL1 Antibody

CAT: 0247-OAAF02871-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0247-OAAF02871-100UGSize:100 µg
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CAS Number
9007-83-4
Gene Name
Atypical chemokine receptor 4
Gene Aliases
Atypical chemokine receptor 4; C-C chemokine receptor type 11; CC chemokine receptor-like 1; C-C CKR-11; CCBP2; CC-CKR-11; CCR10; CCR11; CCR-11; CCRL1; CCX CKR; CCX-CKR; chemocentryx chemokine receptor; chemokine (C-C motif) receptor-like 1; chemokine, cc motif, receptor-like protein 1; CKR-11; orphan seven-transmembrane receptor, chemokine related; PPR1; VSHK1.
Gene ID
51554
Swiss Prot
Q9NPB9
Accession Number
NP_057641.1
Reactivity
Human|Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human CCRL1.
Target
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid.// PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Reconstitution
-20°C
Molecular Weight
39 kDa
Notes
Formerly GWB-ASE058
Fragment
IgG
Specificity
CCRL1 antibody detects endogenous levels of total CCRL1 protein.
NCBI Gene Symbol
ACKR4
Host or Source
Rabbit
Protein Name
Atypical chemokine receptor 4
Gene Name URL
ACKR4

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