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CBFA2T3 Antibody

CAT: 0247-OAAF02383-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF02383-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
CBFA2/RUNX1 partner transcriptional co-repressor 3
Gene Aliases
CBFA2/RUNX1 translocation partner 3; core-binding factor, runt domain, alpha subunit 2; translocated to, 3; ETO2; MTG16; MTG8-related gene 2; MTG8-related protein 2; MTGR2; myeloid translocation gene 8 and 16b; myeloid translocation gene on chromosome 16 protein; protein CBFA2T3; RUNX1T3; zinc finger MYND domain-containing protein 4; ZMYND4.
Gene ID
863
Swiss Prot
O75081|Q0P5Z6
Accession Number
NP_005178.4
Reactivity
Human|Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MTG16.
Target
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199) . Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453) . Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097) . Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097) . Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity) . Plays a role in granulocyte differentiation (PubMed:15231665) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
71 kDa
Notes
Formerly GWB-ASD621
Specificity
MTG16 antibody detects endogenous levels of total MTG16 protein.
NCBI Gene Symbol
CBFA2T3
Host or Source
Rabbit
Protein Name
Protein CBFA2T3
Gene Name URL
CBFA2T3

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