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CCDC88A Antibody

CAT: 0247-OAAF01637-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAAF01637-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Coiled-coil domain containing 88A
Gene Aliases
Akt phosphorylation enhancer; AKT-phosphorylation enhancer; APE; Coiled-coil domain-containing protein 88A; g alpha-interacting vesicle-associated protein; Girders of actin filament; girders of actin filaments; girdin; GIV; GRDN; HkRP1; Hook-related protein 1; KIAA1212; PEHO; PEHOL.
Gene ID
55704
Swiss Prot
Q3V6T2
Accession Number
NP_001129069.1
Reactivity
Human|Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Girdin.
Target
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity) . Enhances phosphoinositide 3-kinase (PI3K) -dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself (By similarity) . Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity) . Essential for the integrity of the actin cytoskeleton and for cell migration (PubMed:16139227) . Required for formation of actin stress fibers and lamellipodia (PubMed:15882442) . May be involved in membrane sorting in the early endosome (PubMed:15882442) . Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (PubMed:27623382) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid.// PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Reconstitution
-20°C
Molecular Weight
216 kDa
Notes
Formerly GWB-ASC975
Fragment
IgG
Specificity
Girdin antibody detects endogenous levels of total Girdin protein.
NCBI Gene Symbol
CCDC88A
Host or Source
Rabbit
Protein Name
Girdin
Gene Name URL
CCDC88A

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