Products for Research Use Only
RegisterLogin

EPB49 Antibody

CAT: 0247-OAAF01027-100UGSize: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OAAF01027-100UGSize:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Click here to learn more about Aviva's By-Request Conjugation Service.//here
CAS Number
9007-83-4
Gene Name
Dematin actin binding protein
Gene Aliases
Dematin; Dematin actin-binding protein; DMT; EPB49; Erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin) .
Gene ID
2039
Swiss Prot
Q08495
Accession Number
NP_001107607.1
Reactivity
Human|Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Dematin.
Target
Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA) . Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Dilution
The optimal working dilution should be determined by the end user.
Format
Liquid
Reconstitution
-20°C
Molecular Weight
45 kDa
Notes
Formerly GWB-ASC430
Specificity
Dematin (Ab-403) antibody detects endogenous levels of total Dematin protein
NCBI Gene Symbol
DMTN
Host or Source
Rabbit
Protein Name
Dematin
Gene Name URL
DMTN

Related Products

CatalogName
AAP61705-100UGEPB49 Peptide - middle region (AAP61705)
OAAN00845-100ULEPB41 Antibody
OACD03251-100ULEPB42 Antibody
OACD00864-1MLEPB41 Antibody
OAAN00845-50ULEPB41 Antibody
OASG00057-100ULEPB41 Antibody
OACD03251-1MLEPB42 Antibody
OAAJ07433-100ULEPB41 Antibody
OACD00865-100ULEPB41 Antibody
OAAN00845-200ULEPB41 Antibody

Alternative Products

CatalogName
70R-10354EPB49 antibody
GTR18786720-01EPB49 Antibody (Center)
GTR18098524EPB49 Rabbit Polyclonal Antibody
MBS3215310-01EPB49 antibody - middle region
GTR18971031EPB49 Antibody Blocking peptide
GTR18353797EPB49 Rabbit Polyclonal Antibody (HRP)
MBS9221839-01EPB49 Antibody (Center) Blocking Peptide
APR15830GPolyclonal EPB49 antibody - middle region
GTR18353799EPB49 Rabbit Polyclonal Antibody (Biotin)
GTR18353798EPB49 Rabbit Polyclonal Antibody (FITC)

Popular Products