CCND3

• Gene Name:

  Cyclin D3

• Gene ID:

  896

• Swiss Prot:

  P30281

• Accession Number:

  NP_001751

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Sheep

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human CCND3

• Target:

  CCND3 encodes a protein that belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.

• Partner Proteins:

  POLR3GL; TFIP11; CDKN1A; CDK6; CDK4; CDK5; MCM10; CDKN1B; CDK2; CDK11B; FAS; SIL1; EIF3K; ATF5; VDR; MAPK6; NME1; MYB; GC; ETV1; RBL2; POLD1; CDK14; APP; RB1; UBC; PPP1CC; PPP1CB; PPP1CA; NCOA2; MAF1; NPDC1; DMTF1; CRABP2; RARA; DTNBP1; AKAP8; EFEMP2; CAS

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Sequence:

  CQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL

• Applications:

  IHC, WB

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 92%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Sheep: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  33kDa

• Protein Length:

  292

• NCBI Gene Symbol:

  CCND3

• Host or Source:

  Rabbit

• Protein Name:

  G1/S-specific cyclin-D3

• Gene Name URL:

  CCND3

• Nucleotide Accession Number:

  NM_001760