Cdk6

• Gene Name:

  Cyclin-dependent kinase 6

• Gene Aliases:

  MCPH12, PLSTIRE

• Gene ID:

  1021

• Swiss Prot:

  Q00534

• Accession Number:

  NP_001250

• Reactivity:

  Human, Mouse, Cow, Dog, Horse, Pig, Rabbit

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human CDK6

• Target:

  CDK6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.

• Partner Proteins:

  PSMA3; DAB1; CDKN2D; CDKN2C; CDKN2B; CCND3; UBC; CCND2; AMY2A; CDKN2A; CDK6; PIGR; DMBT1; WDR33; CDKL3; RB1; CDK4; UCHL1; PML; NUMA1; NFATC3; MYC; MLLT3; MEF2D; MCM2; ISL1; HSP90AA1; HSF1; FOXO3; FOXM1; EZH2; ELK1; DDIT3; ATF6B; CDKN1A; CDC6; CCND1; ZSCAN

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Sequence:

  LLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA

• Applications:

  WB

• Purification:

  Protein A purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1.0 mg/ml

• Homology:

  Cow: 84%; Dog: 84%; Horse: 84%; Human: 100%; Mouse: 76%; Pig: 84%; Rabbit: 84%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  37kDa

• Protein Length:

  326

• NCBI Gene Symbol:

  CDK6

• Host or Source:

  Rabbit

• Protein Name:

  Cyclin-dependent kinase 6

• Gene Name URL:

  CDK6

• Nucleotide Accession Number:

  NM_001259