Haloperidol-d4 N-Oxide

Haloperidol-d4 N-Oxide

• CAS Number: 1246815-56-4
• UNSPSC Description: Haloperidol-d4 N-Oxide is the deuterium labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic[1][2].
• Target Antigen: Dopamine Receptor; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: GPCR/G Protein;Neuronal Signaling;Others
• Field of Research: Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)(=O)CC1)C3=C(C(=C(Cl)C(=C3[2H])[2H])[2H])[2H]
• Molecular Weight: 395.89
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Shah NS, et al. Effects of chlorpromazine and haloperidol on the disposition of mescaline-14C in mice. J Pharmacol Exp Ther. 1973 Aug;186(2):297-304|[3]Furuta Y, et al. Effects of enzyme inhibitors of catecholamine metabolism and of haloperidol on the pancreatic secretion induced by L-DOPA and by dopamine in dogs. Br J Pharmacol. 1973 Jan;47(1):77-84
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported