OPA1 Antibody - N-terminal region

• Gene Name:

  Optic atrophy 1 (autosomal dominant)

• Gene Aliases:

  NPG, NTG, MGM1, BERHS, largeG, MTDPS14

• Gene ID:

  4976

• Swiss Prot:

  E5KLK2

• Accession Number:

  NP_570844

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

• Target:

  This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

• Partner Proteins:

  UBC; PARK2; MYC; HSP90AA5P; NIT2; HTRA2; NPTX1; NDUFS8; NDUFS1; NDUFA9; ILF3; HADHB; ECH1; DNASE2; APP; SMAD3; SMAD2; CAND1; CUL3; ELAVL1; MME

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Sequence:

  SPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERL

• Applications:

  WB

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  102kDa

• Protein Length:

  924

• NCBI Gene Symbol:

  OPA1

• Host or Source:

  Rabbit

• Protein Name:

  Mitochondrial dynamin-like 120 kDa protein EMBL ADP90061.1

• Gene Name URL:

  OPA1

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_130831