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Flucytosine

CAT: 0804-HY-B0139-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0139-01Size:500 mg
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Description
Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells[1][2][3].
CAS Number
2022-85-7
Product Name Alternative
5-Fluorocytosine; NSC 103805; Ro 2-9915
UNSPSC
12352005
Hazard Statement
H361
Target
Antibiotic; Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Flucytosine.html
Purity
99.99
Solubility
DMSO : 16.67 mg/mL (ultrasonic) |H2O : 6.67 mg/mL (ultrasonic)
Smiles
O=C1NC=C(F)C(N)=N1
Molecular Formula
C4H4FN3O
Molecular Weight
129.09
Precautions
H361
References & Citations
[1]Vermes A, et al. Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother. 2000 Aug;46 (2) :171-9.|[2]You MH, et al. Cytosine deaminase-producing human mesenchymal stem cells mediate an antitumor effect in a mouse xenograft model. J Gastroenterol Hepatol. 2009 Aug;24 (8) :1393-400.|[3]Iovannitti C, et al. Itraconazole and flucytosine+itraconazole combination in the treatment of experimental cryptococcosis in hamsters. Mycoses. 1995 Nov-Dec;38 (11-12) :449-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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