TXNIP Antibody - C-terminal region

• Gene Name:

  Thioredoxin interacting protein

• Gene Aliases:

  THIF, VDUP1, ARRDC6, HHCPA78, EST01027

• Gene ID:

  10628

• Swiss Prot:

  Q9H3M7

• Accession Number:

  NP_006463

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Sheep

• Immunogen:

  The immunogen is a synthetic peptide directed towards the C terminal region of human TXNIP

• Target:

  TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells.

• Partner Proteins:

  UBC; DDIT4; ECD; TXN; TP53; SMURF2; UL49; ITCH; ELAVL1; FHL1; ZBTB32; ZBTB16; SCEL; HDAC1; TXNRD1; KPNA2

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Sequence:

  DTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPP

• Applications:

  WB

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  44kDa

• Protein Length:

  391

• NCBI Gene Symbol:

  TXNIP

• Host or Source:

  Rabbit

• Protein Name:

  Thioredoxin-interacting protein

• Gene Name URL:

  TXNIP

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_006472