Jervine

• Description:

  Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM[1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties[2].

• Product Name Alternative:

  11-Ketocyclopamine

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H360

• Target:

  Hedgehog; Smo

• Type:

  Natural Products

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Jervine.html

• Purity:

  99.28

• Solubility:

  DMSO : 1 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@]2 ([H]) [C@]3 (C) C (C[C@@H] (O) CC3) =CC[C@@]2 ([H]) [C@]4 ([H]) CC[C@]5 (O[C@@]6 ([H]) [C@@] ([C@H]5C) ([H]) NC[C@@H] (C) C6) C (C) =C41

• Molecular Formula:

  C27H39NO3

• Molecular Weight:

  425.60

• Precautions:

  H301, H360

• References & Citations:

  [1]Williams JA, et al.Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basalcell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100 (8) :4616-21.|[2]Dumlu FA, et al.Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album.Phytomedicine. 2019 Mar 1;55:191-199.|[3]Ghezali L, et al.Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect.Exp Cell Res. 2013 Apr 15;319 (7) :1043-53.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  469-59-0