Jervine

• Target:

  Hedgehog/Smoothened|||Smo

• Related Pathways:

  Stem Cells|||GPCR/G Protein

• Purity:

  0.9986

• Bioactivity:

  The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.

• Smiles:

  [H][C@@]12NC[C@@H](C)C[C@H]1O[C@]1(CC[C@]3([H])C(C(=O)[C@@]4([H])[C@@]3([H])CC=C3C[C@@H](O)CC[C@]43C)=C1C)[C@@H]2C

• Molecular Formula:

  C27H39NO3

• Molecular Weight:

  425.6

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  469-59-0