EZH2 (ARP38470_P050)

• Gene Name:

  Enhancer of zeste homolog 2 (Drosophila)

• Gene Aliases:

  WVS, ENX1, KMT6, WVS2, ENX-1, EZH2b, KMT6A

• Gene ID:

  2146

• Swiss Prot:

  Q15910

• Accession Number:

  NP_004447.2

• Reactivity:

  Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

• Immunogen:

  The immunogen is a synthetic peptide directed towards the N terminal region of human EZH2

• Target:

  EZH2 is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems.

• Partner Proteins:

  FBXW11; CEP63; HOTAIR; EED; BRCA1; SUZ12; SNAI1; SRSF1; SDCBP; UPF1; RBBP7; RBBP4; RAP1GAP; PLEC; PKM; POTEE; DHX36; AEBP2; HIST4H4; KLC4; SERPINB12; PHF5A; FIP1L1; FBXL18; CPSF7; DDX3X; DBN1; SLC25A10; COPB1; CALML3; ATP5C1; ATP5B; ATP2A2; ARG1; AR; ANXA

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Sequence:

  KGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQE

• Applications:

  IHC, WB

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.5 mg/ml

• Homology:

  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

• Format:

  Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Reconstitution:

  For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

• Molecular Weight:

  85kDa

• Specificity:

  From peptide immunogen, will recognize all 5 isoforms.

• Protein Length:

  751

• NCBI Gene Symbol:

  EZH2

• Host or Source:

  Rabbit

• Protein Name:

  Histone-lysine N-methyltransferase EZH2

• Gene Name URL:

  EZH2

• Nucleotide Accession Number:

  NM_001203247