LY 3000328

• Target:

  Cysteine Protease

• Related Pathways:

  Proteases/Proteasome

• Purity:

  0.9954

• Bioactivity:

  LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S with IC50 values ??of 7.7 and 1.67 nM for human and mouse cathepsin S, respectively. LY 3000328 (Cathepsin S inhibitor) may slow or prevent abdominal aortic aneurysm (AAA) expansion and/or reduce the risk of AAA rupture by inhibiting cathepsin S-mediated degradation of extracellular matrix proteins, elastin and collagen.

• Smiles:

  CNC(=O)O[C@H]1COc2ccc(cc2[C@@H]1NC(=O)c1ccc(F)cc1)N1CCN(CC1)C1COC1

• Molecular Formula:

  C25H29FN4O5

• Molecular Weight:

  484.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1373215-15-6