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PRN1371

CAT: 0931-TQ0015-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-TQ0015-02Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1802929-43-6
Target
CSF-1R, c-Fms, FGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9972
Bioactivity
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R) .
Smiles
CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Molecular Formula
C26H30Cl2N6O4
Molecular Weight
561.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Prn-1371

pan FGFR Inhibitor PRN1371 is a highly specific covalent inhibitor of human fibroblast growth factor receptor types 1, 2, 3 and 4 (FGFR1-4) with potential antiangiogenic and antineoplastic activities. FGFR1-4 tyrosine kinase inhibitor PRN1371 specifically binds to a conserved cysteine residue in the glycine-rich loop in FGFRs and inhibits their tyrosine kinase activity, which may result in the inhibition of both tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases, which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation, proliferation and survival, and in tumor angiogenesis. This agent potently inhibits FGFR1-4 but does not inhibit other tyrosine kinases, even those that share the conserved cysteine, which may improve therapeutic responses and decrease toxicity when compared with less selective inhibitors.

CAS Number1802929-43-6
PubChem CID118295624
IUPAC Name6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one
Molecular FormulaC26H30Cl2N6O4
Molecular Weight561.5
XLogP3.5
Topological Polar Surface Area100
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Heavy Atom Count38
Formal Charge0
Complexity870
SMILES
CNC1=NC=C2C=C(C(=O)N(C2=N1)CCCN3CCN(CC3)C(=O)C=C)C4=C(C(=CC(=C4Cl)OC)OC)Cl
InChI
InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
InChIKey
PUIXMSRTTHLNKI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Prn-1371
CAS: 1802929-43-6
CID: 118295624
Formula: C26H30Cl2N6O4
MW: 561.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight561.5
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass560.1705588
Monoisotopic Mass560.1705588
Topological Polar Surface Area100 Ų
Heavy Atom Count38
Formal Charge0
Complexity870
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BP179867-01PRN1371
A19340-5PRN1371 5mg
A19340-2PRN1371 2mg
A19340-1PRN1371 1mg
A19340-100PRN1371 100mg
A19340-50PRN1371 50mg
A19340-25PRN1371 25mg
A19340-10PRN1371 10mg
A19340-10mM-DPRN1371 10mM * 1mL in DMSO

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