Antisauvagine-30

• Target:

  CRFR

• Related Pathways:

  GPCR/G Protein

• Bioactivity:

  Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2? and rat CRF1 receptors respectively) . Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2? cells (pA2 = 8.49) . Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.

• Molecular Formula:

  C161H274N48O46S

• Molecular Weight:

  3650.29

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  220673-95-0