Conantokin G

• Target:

  IGluR

• Related Pathways:

  Membrane transporter/Ion channel|||Neuroscience

• Bioactivity:

  GluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM) ; also inhibits NMDA-evoked responses in oocytes expressing GluN2B (formally NR2B), but not GluN2A (formally NR2A), subunits (IC50 ~300 nM) . Exhibits neuroprotective properties in vivo and in vitro.

• Smiles:

  [C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CCC(O)=O)=O)CC(C(O)=O)C(O)=O)=O)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N)=O)=O)CO)=O)CCCCN)=O)CC(C(O)=O)C(O)=O)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CC(C)C)=O)CC(C(O)=O)C(O)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CC(C(O)=O)C(O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CC(C(O)=O)C(O)=O

• Molecular Formula:

  C88H138N26O44

• Molecular Weight:

  2264.21

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  93438-65-4