Conantokin-G

• Description:

  Conantokin-G is a conopeptide that has been isolated from the venom of the cone Conus geographus. Conantokin-G selectively inhibits NR2B containing N-methyl-D-aspartate receptors (NMDAR) with a high specificity. Thus, Conantokin-G inhibits in a concentration-dependent manner the Ca2+ influx leading to a neuroprotective effect against NMDA-induced excitotoxicity. Conantokin-G was shown to block NMDA-evoked currents in murine cortical neurons with an IC50 value of around 480 nM.

• Specifications:

  Selective inhibitor of NR2B-containing NMDAR

• Target:

  NMDA receptors

• Sequence:

  GEXXLQXNQXLIRXKSN (X=Gla)

• Peptide Number:

  08CON009

• N Terminal Sequence:

  H

• C Terminal Sequence:

  NH2

• CAS Number:

  93438-65-4