CTOP

• Target:

  Opioid Receptor

• Related Pathways:

  Neuroscience|||GPCR/G Protein|||Endocrinology/Hormones

• Bioactivity:

  Potent and selective ? opioid receptor antagonist (Ki values are 0.96 and >10,000 nM for ? and ? receptors respectively) . Causes behavioral effects on central administration in vivo. Also increases K+ currents in rat locus ceruleus neurons in vitro via a ? receptor independent mechanism.

• Smiles:

  C(C=1C=2C(NC1)=CC=CC2)[C@H]3NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@@H](NC([C@@H](CC5=CC=CC=C5)N)=O)CSSC(C)(C)[C@@H](C(N[C@@H]([C@@H](C)O)C(N)=O)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CCCN)NC3=O)[H]

• Molecular Formula:

  C50H67N11O11S2

• Molecular Weight:

  1062.28

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  103429-31-8