Mambalgin 1

• Target:

  Sodium Channel

• Related Pathways:

  Membrane transporter/Ion channel

• Bioactivity:

  Selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively) . Binds to closed/inactive channel. Selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Increases latency of withdrawal response in mouse tail-flick and paw-flick tests. Analgesic.

• Molecular Formula:

  C272H429N85O84S10

• Molecular Weight:

  6554.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1609937-15-6